Among the large, diverse set of mammalian long noncoding RNAs (lncRNAs), long noncoding primary microRNAs (lnc-pri-miRNAs) are those that host miRNAs. Whether lnc-pri-miRNA loci have important ...

microRNAs (miRNAs) are essential regulators of gene expression in diverse biological processes and disease states. They are short 22-nt noncoding RNAs that bind to mRNA targets via partial base ...

Potential of Field Is Catalyst for Emerging Diagnostic and Therapeutic Strategies As key regulators of gene expression and cellular machinery, microRNAs may be the most significant discovery in ...

Nibbler (Nbr) is a 3′-to-5′ exoribonuclease whose catalytic 3′-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional ...

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...

Analyzing gene expression can provide a roadmap for deciphering the role of specific genes or elaborating critical players in functional metabolic pathways. Companies are pursuing solutions to better ...

The 2024 Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA and its pivotal role in post-transcriptional gene regulation.

A research team led by scientists from the Hong Kong University of Science and Technology (HKUST) has revealed how secondary structure RNA elements control the cleavage activity of the DICER enzyme in ...